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19914829
Source:
http://linkedlifedata.com/resource/pubmed/id/19914829
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0006050
,
umls-concept:C0030946
,
umls-concept:C0043481
,
umls-concept:C0243077
pubmed:issue
1
pubmed:dateCreated
2010-2-3
pubmed:abstractText
A series of benzylidene cyclopentenedione-based inhibitors, acting through covalent modification of the active site of botulinum neurotoxin A light chain metalloprotease, are reported.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/AI080671
,
http://linkedlifedata.com/resource/pubmed/grant/N01 AI030050
,
http://linkedlifedata.com/resource/pubmed/grant/N01-AI30050
,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI080671-01A1
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19914829-15823014
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19914829-16597152
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19914829-17524984
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19914829-17889852
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19914829-17951059
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19914829-17962024
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Benzylidene Compounds
,
http://linkedlifedata.com/resource/pubmed/chemical/Botulinum Toxins, Type A
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclopentanes
,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases
,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc
,
http://linkedlifedata.com/resource/pubmed/chemical/cyclopentenone
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1464-3405
pubmed:author
pubmed-author:BarbieriJoseph TJT
,
pubmed-author:CapkováKaterinaK
,
pubmed-author:HixonMark SMS
,
pubmed-author:JandaKim DKD
,
pubmed-author:JohnsonEric AEA
,
pubmed-author:PellettSabineS
pubmed:copyrightInfo
Copyright 2009 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
206-8
pubmed:dateRevised
2011-7-18
pubmed:meshHeading
pubmed-meshheading:19914829-Benzylidene Compounds
,
pubmed-meshheading:19914829-Botulinum Toxins, Type A
,
pubmed-meshheading:19914829-Catalytic Domain
,
pubmed-meshheading:19914829-Cyclopentanes
,
pubmed-meshheading:19914829-Metalloendopeptidases
,
pubmed-meshheading:19914829-Protease Inhibitors
,
pubmed-meshheading:19914829-Zinc
pubmed:year
2010
pubmed:articleTitle
Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.
pubmed:affiliation
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
pubmed:publicationType
Journal Article
,
Research Support, N.I.H., Extramural