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pubmed-article:19914548pubmed:abstractTextThere is accumulating data on the clinical benefit of aromatase inhibitors in the adjuvant treatment of early-stage breast cancer in postmenopausal women. The Breast International Group (BIG) 1-98 study is a randomized, phase 3, double-blind trial comparing four adjuvant endocrine treatments of 5 years duration in postmenopausal women with hormone-receptor-positive breast cancer: letrozole or tamoxifen monotherapy, sequential treatment with tamoxifen followed by letrozole, or vice versa. This article summarizes data presented at the 2009 St. Gallen early breast cancer conference: an update on the monotherapy arms of the BIG 1-98 study, and results from the sequential treatment arms. Implications for daily practice from BIG 1-98 and from other adjuvant trials will be discussed.lld:pubmed
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pubmed-article:19914548pubmed:year2009lld:pubmed
pubmed-article:19914548pubmed:articleTitleUpdate of the BIG 1-98 Trial: where do we stand?lld:pubmed
pubmed-article:19914548pubmed:affiliationBreast Center, Cantonal Hospital, St. Gallen, Switzerland.lld:pubmed
pubmed-article:19914548pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19914548pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:19914548pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:19914548pubmed:publicationTypeMulticenter Studylld:pubmed