Whilst an association between the tau gene (MAPT)-containing H1 haplotype and supranuclear gaze palsy (PSP) has long been recognized, the effect of H1 on risk for Parkinson's disease (PD) has remained more contentious.
Department of Neuroscience, Mayo Clinic, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinsons Disease Research Center of Excellence, Jacksonville, FL 32224, USA. wider.christian@mayo.edu