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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-1
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pubmed:abstractText |
We have previously shown that, in vitro, monoclonal antibodies (mAbs) labeled with the Auger electron emitter (125)I are more cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the in vivo biologic efficiency of internalizing and noninternalizing (125)I-labeled mAbs for the treatment of small solid tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1535-5667
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2033-41
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pubmed:dateRevised |
2011-11-3
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pubmed:meshHeading |
pubmed-meshheading:19910417-Animals,
pubmed-meshheading:19910417-Antibodies, Monoclonal,
pubmed-meshheading:19910417-Biological Transport,
pubmed-meshheading:19910417-Cell Line, Tumor,
pubmed-meshheading:19910417-Female,
pubmed-meshheading:19910417-Iodine Radioisotopes,
pubmed-meshheading:19910417-Isotope Labeling,
pubmed-meshheading:19910417-Mice,
pubmed-meshheading:19910417-Peritoneal Neoplasms,
pubmed-meshheading:19910417-Radioimmunotherapy,
pubmed-meshheading:19910417-Radiometry,
pubmed-meshheading:19910417-Survival Rate,
pubmed-meshheading:19910417-Tissue Distribution,
pubmed-meshheading:19910417-Tumor Burden
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pubmed:year |
2009
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pubmed:articleTitle |
Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.
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pubmed:affiliation |
Institut de Recherche en Cancérologie de Montpellier, INSERM, U896, Montpellier, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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