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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-8
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pubmed:abstractText |
Polycystic ovary syndrome (PCOS) characterized by chronic anovulation and hyperandrogenism is highly associated with obesity and insulin resistance (IR), two key features of nonalcoholic steatohepatitis (NASH). NASH often leads to cirrhosis, including portal hypertension, liver failure, and hepatocellular carcinoma as long-term complications. The caspase 3-cleaved fragment of cytokeratin 18 (CK18) emerging from ongoing cell death during apoptosis process has been established as a serum marker for NASH. This study was conducted to evaluate the prevalence of NASH in PCOS patients by caspase-cleaved CK18 measurement.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1945-7197
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pubmed:author |
pubmed-author:BechmannLars PLP,
pubmed-author:BensonSvenS,
pubmed-author:CanbayAliA,
pubmed-author:DietzTiinaT,
pubmed-author:EichnerStefanieS,
pubmed-author:GerkenGuidoG,
pubmed-author:HahnSusanneS,
pubmed-author:JanssenOnno EOE,
pubmed-author:LahnerHaraldH,
pubmed-author:MannKlausK,
pubmed-author:TanSusanneS
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pubmed:issnType |
Electronic
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
343-8
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pubmed:meshHeading |
pubmed-meshheading:19906783-Adult,
pubmed-meshheading:19906783-Apoptosis,
pubmed-meshheading:19906783-Biological Markers,
pubmed-meshheading:19906783-Case-Control Studies,
pubmed-meshheading:19906783-Disease Progression,
pubmed-meshheading:19906783-Fatty Liver,
pubmed-meshheading:19906783-Female,
pubmed-meshheading:19906783-Humans,
pubmed-meshheading:19906783-Metabolic Diseases,
pubmed-meshheading:19906783-Phenotype,
pubmed-meshheading:19906783-Polycystic Ovary Syndrome,
pubmed-meshheading:19906783-Prevalence,
pubmed-meshheading:19906783-Risk Factors,
pubmed-meshheading:19906783-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome.
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pubmed:affiliation |
Department of Endocrinology and Division of Laboratory Research, University of Duisburg-Essen, 45122 Essen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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