Source:http://linkedlifedata.com/resource/pubmed/id/19896697
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-2-17
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| pubmed:abstractText |
Cell division cycle 7 is a widely expressed protein kinase implicated in cell division, cell cycle checkpoint mechanisms, and cancer progression. To determine the relationship of cell division cycle 7 protein expression with tumor phenotype, molecular features and prognosis, 2197 highly characterized breast carcinomas were analyzed on a tissue microarray. Detectable cell division cycle 7 expression was found in 1088 (57%) of breast cancer specimens and 228 (11.9%) exhibited a moderate or strong expression. High levels of cell division cycle 7 expression were significantly related to medullary histotype (P < .0001); high tumor grade (P < .0001); negative estrogen receptor status (P < .0001); high Ki67 expression level (P < .0001); p53 and p16 overexpression (P < .0001); and amplification of HER2 (P < .0001), c-myc (P < .0001), MDM2 (P = .043), CCND1 (P = .0084), and ESR1 (P = .0012) as well as with the number of amplified genes (P < .0001). There was also a tendency towards worse prognosis in cell division cycle 7 positive as compared to negative breast cancers. The relationship between cell division cycle 7 and number of amplifications was independent from tumor proliferation raising the possibility of a direct influence of cell division cycle 7 expression for amplification development. In conclusion, cell division cycle 7 is a replication associated protein with relationships to gene amplification and genomic instability in breast carcinomas. These data support the potential utility of newly developed small molecule cell division cycle 7 inhibitors as a therapeutic alternative in at least a subset of breast carcinomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1532-8392
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| pubmed:author |
pubmed-author:BokemeyerCarstenC,
pubmed-author:ChoschzickMatthiasM,
pubmed-author:HeilenkötterUweU,
pubmed-author:JaenickeFritzF,
pubmed-author:LebeauAnnetteA,
pubmed-author:MarxAndreas HAH,
pubmed-author:SauterGuidoG,
pubmed-author:SchwarzJörgJ,
pubmed-author:SimonRonaldR,
pubmed-author:TerraccianoLuigiL,
pubmed-author:TharunLarsL
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| pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
41
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
358-65
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| pubmed:meshHeading |
pubmed-meshheading:19896697-Breast Neoplasms,
pubmed-meshheading:19896697-Carcinoma,
pubmed-meshheading:19896697-Cell Cycle,
pubmed-meshheading:19896697-Cell Cycle Proteins,
pubmed-meshheading:19896697-Chi-Square Distribution,
pubmed-meshheading:19896697-Disease Progression,
pubmed-meshheading:19896697-Female,
pubmed-meshheading:19896697-Gene Amplification,
pubmed-meshheading:19896697-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19896697-Genetic Association Studies,
pubmed-meshheading:19896697-Humans,
pubmed-meshheading:19896697-Immunohistochemistry,
pubmed-meshheading:19896697-Ki-67 Antigen,
pubmed-meshheading:19896697-Phenotype,
pubmed-meshheading:19896697-Prognosis,
pubmed-meshheading:19896697-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19896697-Tissue Array Analysis
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| pubmed:year |
2010
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| pubmed:articleTitle |
Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer.
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| pubmed:affiliation |
Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
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| pubmed:publicationType |
Journal Article
|