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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-9
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pubmed:abstractText |
The hypoxia-inducible factor (HIF)-dependent transcriptional response is often very pronounced in hypoxic microregions of solid malignant tumours, leading to secretion of pro-angiogenic factors and activation of a hypoxia-tolerant, glycolytic metabolism. Here, the influence of the microenvironment of tumour-initiating cells as a factor determining intertumoural variations in the relative contributions of both processes has been examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1362-3095
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
981-8
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pubmed:meshHeading |
pubmed-meshheading:19895275-Animals,
pubmed-meshheading:19895275-Anoxia,
pubmed-meshheading:19895275-Cell Line, Tumor,
pubmed-meshheading:19895275-Glucose Transporter Type 1,
pubmed-meshheading:19895275-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19895275-Immunohistochemistry,
pubmed-meshheading:19895275-Ki-67 Antigen,
pubmed-meshheading:19895275-Male,
pubmed-meshheading:19895275-Neovascularization, Pathologic,
pubmed-meshheading:19895275-Oxygen,
pubmed-meshheading:19895275-Rats,
pubmed-meshheading:19895275-Rats, Sprague-Dawley,
pubmed-meshheading:19895275-Sarcoma, Experimental
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pubmed:year |
2009
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pubmed:articleTitle |
Solid tumours arising from differently pre-oxygenated cells: comparable growth rates despite dissimilar tissue oxygenation.
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pubmed:affiliation |
Department of Radiooncology and Radiotherapy, University Medical Center, Mainz, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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