Source:http://linkedlifedata.com/resource/pubmed/id/19889506
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2010-2-1
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pubmed:abstractText |
PAC-1 was subjected to acid degradation conditions at 80 degrees C for 10h. Four unknown degradation products were isolated from PAC-1 by semi-preparative high performance liquid chromatography using isocratic elution conditions. Based on the ESI-MS and NMR spectral data the structures of these four degradation products were characterized as 2-allyl-6-((E)-((E)-(2-hydroxy-3-(2-hydroxypropyl)benzylidene)hydrazono)methyl)phenol, 2-hydroxy-3-(2-propenyl)-[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazone, 6,6'-(1E,1'E)-hydrazine-1,2-diylidenebis(methan-1-yl-1-ylidene)bis(2-(2-hydroxypropyl)phenol) and 2-hydroxy-3-(2-hydroxypropyl)benzaldehyde.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-264X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2009 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
965-8
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pubmed:meshHeading |
pubmed-meshheading:19889506-Antineoplastic Agents,
pubmed-meshheading:19889506-Chromatography, High Pressure Liquid,
pubmed-meshheading:19889506-Drug Stability,
pubmed-meshheading:19889506-Hydrazones,
pubmed-meshheading:19889506-Hydrogen-Ion Concentration,
pubmed-meshheading:19889506-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19889506-Molecular Structure,
pubmed-meshheading:19889506-Piperazines,
pubmed-meshheading:19889506-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:19889506-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:19889506-Temperature,
pubmed-meshheading:19889506-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Isolation and structure elucidation of degradation products in the potential anticancer drug PAC-1.
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pubmed:affiliation |
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
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pubmed:publicationType |
Journal Article
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