|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1991-2-22
|
|
pubmed:abstractText |
Conditioned media from human peripheral blood leucocytes treated with lipopolysaccharide (LPS) induced a marked increase in the 3H-thymidine incorporation of cultured mesangial cells at low serum concentration (four to six times higher than control). Two sizes (100-70 and 8-12 kD) of monocyte-derived mesangial cell proliferating factors (MDF) were separated by column chromatography. Their peaks were distinct from those of thymocyte proliferating activity. The addition of anti-human interleukin-1 (IL-1) or anti-recombinant human interleukin-6 (IL-6) antibody to the fractionated MDF failed to have any effect on the mitogenic activity toward mesangial cells. The addition of anti-human platelet-derived growth factor (PDGF) antibody to the low molecular weight fraction decreased mesangial cell mitogenic activity (40-60% of control), but addition to the higher fraction did not (80-100% of control). From these data it seems that a large portion of the monocyte-derived mesangial cell growth factor was not comprised of IL-1 or IL-6 but of PDGF-like molecules; and that there is an unknown mesangial cell proliferating factor (or factors) besides IL-1, IL-6 and PDGF.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-2416458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-2592764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-2783498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-2842769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-2845810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-3865890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-56649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-6121416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-6219219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-6605992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-6758240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-7446118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1988227-7446119
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0009-9104
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
83
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
182-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1988227-Adult,
pubmed-meshheading:1988227-Antibodies,
pubmed-meshheading:1988227-Cell Division,
pubmed-meshheading:1988227-Cells, Cultured,
pubmed-meshheading:1988227-Chemical Fractionation,
pubmed-meshheading:1988227-Chromatography, Gel,
pubmed-meshheading:1988227-Chromatography, High Pressure Liquid,
pubmed-meshheading:1988227-Glomerular Mesangium,
pubmed-meshheading:1988227-Growth Substances,
pubmed-meshheading:1988227-Humans,
pubmed-meshheading:1988227-Interleukin-1,
pubmed-meshheading:1988227-Interleukin-6,
pubmed-meshheading:1988227-Leukocytes, Mononuclear,
pubmed-meshheading:1988227-Mitosis,
pubmed-meshheading:1988227-Platelet-Derived Growth Factor,
pubmed-meshheading:1988227-Recombinant Proteins,
pubmed-meshheading:1988227-Thymus Gland
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Production by cultured human monocytes of mesangial cell proliferation factor(s) differing from interleukin-1 and interleukin-6.
|
|
pubmed:affiliation |
Department of Immunology, Niigata University School of Medicine, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
