|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007115,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026882,
umls-concept:C0038952,
umls-concept:C0334227,
umls-concept:C0567416,
umls-concept:C0812241,
umls-concept:C1514485,
umls-concept:C1704259,
umls-concept:C1705987
|
|
pubmed:dateCreated |
2009-11-12
|
|
pubmed:abstractText |
Thyroid carcinomas show a high prevalence of mutations in the oncogene BRAF which are inversely associated with RAS or RET/PTC oncogenic activation. The possibility of using inhibitors on the BRAF pathway as became an interesting therapeutic approach. In thyroid cancer cells the target molecules, implicated on the cellular effects, mediated by inhibition of BRAF are not well established. In order to fill this lack of knowledge we studied the proliferation and survival pathways and associated molecules induced by BRAF inhibition in thyroid carcinoma cell lines harbouring distinct genetic backgrounds.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-10891505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-11566613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-12068308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-12781369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-12881714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-12917419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-14500344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-14602780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-14668801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-15035987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-15095090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-15208655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-15208680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-15466206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-15735667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16007148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16007203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16254036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16424035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16452220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16507829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16533790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16551863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-16924241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17016424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17179987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17363500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17374713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17384584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17496909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17575107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-17725429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-18098337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-18541894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-18713817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19878585-18799615
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2407
|
|
pubmed:author |
pubmed-author:FigueiredoJoanaJ,
pubmed-author:GonçalvesJoanaJ,
pubmed-author:MeirelesAna MAM,
pubmed-author:PretoAnaA,
pubmed-author:RebochoAna PAP,
pubmed-author:RochaAna SAS,
pubmed-author:SecaHugoH,
pubmed-author:SerucaRaquelR,
pubmed-author:SoaresPaulaP,
pubmed-author:Sobrinho-SimõesManuelM,
pubmed-author:VasconcelosHelena MHM
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
387
|
|
pubmed:dateRevised |
2010-9-28
|
|
pubmed:meshHeading |
pubmed-meshheading:19878585-Apoptosis,
pubmed-meshheading:19878585-Apoptosis Regulatory Proteins,
pubmed-meshheading:19878585-Benzenesulfonates,
pubmed-meshheading:19878585-Cell Line, Tumor,
pubmed-meshheading:19878585-Cell Proliferation,
pubmed-meshheading:19878585-Cell Survival,
pubmed-meshheading:19878585-Humans,
pubmed-meshheading:19878585-Mutation,
pubmed-meshheading:19878585-Phosphorylation,
pubmed-meshheading:19878585-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:19878585-Pyridines,
pubmed-meshheading:19878585-Signal Transduction,
pubmed-meshheading:19878585-Thyroid Neoplasms
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.
|
|
pubmed:affiliation |
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465, Porto, Portugal. apreto@ipatimup.pt
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
