Source:http://linkedlifedata.com/resource/pubmed/id/19877803
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-6-2
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| pubmed:abstractText |
The authors report a rare case of slowly progressive neuronal death associated with postischemic hyperperfusion in cortical laminar necrosis after radial artery/external carotid artery-middle cerebral artery bypass graft surgery for an intracavernous carotid artery aneurysm. Under barbiturate protection, a 69-year-old man underwent high-flow bypass surgery combined with carotid artery sacrifice for a symptomatic intracavernous aneurysm. The patient became restless postoperatively, and this restlessness peaked on postoperative Day (POD) 7. Diffusion-weighted and FLAIR MR images obtained on PODs 1 and 7 revealed subtle cortical hyperintensity in the temporal cortex subjected to temporary occlusion. On POD 13, (123)I-iomazenil ((123)I-IMZ) SPECT clearly showed increased distribution on the early image and mildly decreased binding on the delayed image with count ratios of the affected-unaffected corresponding regions of interest of 1.23 and 0.84, respectively, suggesting postischemic hyperperfusion. This was consistent with the finding on (123)I-iodoamphetamine SPECT. Of note, neuronal density in the affected cortex on the delayed (123)I-IMZ image further decreased to the affected/unaffected ratio of 0.44 on POD 55 during the subacute stage when characteristic cortical hyperintensity on T1-weighted MR imaging, typical of cortical laminar necrosis, was emerging. The affected cortex showed marked atrophy 8 months after the operation despite complete neurological recovery. This report illustrates, for the first time, dynamic neuroradiological correlations between slowly progressive neuronal death shown by (123)I-IMZ SPECT and cortical laminar necrosis on MR imaging in human stroke.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1933-0693
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
112
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1254-9
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| pubmed:meshHeading |
pubmed-meshheading:19877803-Aged,
pubmed-meshheading:19877803-Atrophy,
pubmed-meshheading:19877803-Blood Flow Velocity,
pubmed-meshheading:19877803-Brain Damage, Chronic,
pubmed-meshheading:19877803-Brain Edema,
pubmed-meshheading:19877803-Brain Ischemia,
pubmed-meshheading:19877803-Carotid Artery Diseases,
pubmed-meshheading:19877803-Cavernous Sinus,
pubmed-meshheading:19877803-Cell Death,
pubmed-meshheading:19877803-Cerebral Angiography,
pubmed-meshheading:19877803-Cerebral Cortex,
pubmed-meshheading:19877803-Cerebral Revascularization,
pubmed-meshheading:19877803-Diffusion Magnetic Resonance Imaging,
pubmed-meshheading:19877803-Dominance, Cerebral,
pubmed-meshheading:19877803-Follow-Up Studies,
pubmed-meshheading:19877803-Humans,
pubmed-meshheading:19877803-Image Processing, Computer-Assisted,
pubmed-meshheading:19877803-Imaging, Three-Dimensional,
pubmed-meshheading:19877803-Intracranial Aneurysm,
pubmed-meshheading:19877803-Magnetic Resonance Angiography,
pubmed-meshheading:19877803-Male,
pubmed-meshheading:19877803-Nerve Degeneration,
pubmed-meshheading:19877803-Neurologic Examination,
pubmed-meshheading:19877803-Postoperative Complications,
pubmed-meshheading:19877803-Reperfusion Injury,
pubmed-meshheading:19877803-Temporal Lobe,
pubmed-meshheading:19877803-Tomography, Emission-Computed, Single-Photon
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| pubmed:year |
2010
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| pubmed:articleTitle |
Slowly progressive neuronal death associated with postischemic hyperperfusion in cortical laminar necrosis after high-flow bypass for a carotid intracavernous aneurysm.
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| pubmed:affiliation |
Department of Neurosurgery, National Cardiovascular Center, Osaka, Japan. kiihara@hsp.ncvc.go.jp
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| pubmed:publicationType |
Journal Article,
Case Reports
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