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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-4
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pubmed:abstractText |
The complexity of immunoregulation has focused attention on the CD4+ T "suppressor" regulatory cell (Treg), which helps maintain balance between immunity and tolerance. An immunoregulatory T-cell population that upon activation amplifies cellular immune responses was described in murine models more than 30 years ago; however, no study has yet identified a naturally occurring T "inducer" cell type. Here, we report that the ectoenzyme CD39/NTPDase1 (ecto-nucleoside triphosphate diphosphohydrolase 1) helps to delineate a novel population of human "inducer" CD4+ T cells (Tind) that significantly increases the proliferation and cytokine production of responder T cells in a dose-dependent manner. Furthermore, this unique Tind subset produces a distinct repertoire of cytokines in comparison to the other CD4+ T-cell subsets. We propose that this novel CD4+ T-cell population counterbalances the suppressive activity of suppressor Treg in peripheral blood and serves as a calibrator of immunoregulation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-10470077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-10837065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-11390435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-12097383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-12413734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-12658268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-12658270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-15032588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-15466453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-15516964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-15785761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-15893493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-16200070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-16557261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-16784779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-16818676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-16818678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-17374358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-17449799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-17502665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-17982112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-18154618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-18404478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-19172726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-2523712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-6242848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-6282762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-6454751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-6785749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19877008-9077545
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1521-4141
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pubmed:author |
pubmed-author:AandahlEinar MEM,
pubmed-author:AnderssonJanJ,
pubmed-author:BarbourJason DJD,
pubmed-author:Eccles-JamesIjeoma GIG,
pubmed-author:JhaAashish RAR,
pubmed-author:KallasEsper GEG,
pubmed-author:LanteriMarionM,
pubmed-author:LealFabio EFE,
pubmed-author:NdhlovuLishomwa CLC,
pubmed-author:NixonDouglas FDF,
pubmed-author:NorrisPhilip JPJ,
pubmed-author:TaskénKjetilK,
pubmed-author:TorheimEirik AEA,
pubmed-author:WachterDouglas JDJ
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
134-41
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties.
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pubmed:affiliation |
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, and HIV/AIDS Division, San Francisco General Hospital, San Francisco, CA 94110, USA. lndhlovu@medsfgh.ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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