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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-2-21
|
| pubmed:abstractText |
Aluminum toxicity is a documented cause of encephalopathy, anemia, and osteomalacia. Excretion is primarily renal; therefore, patients with renal insufficiency are at risk for aluminum accumulation and toxicity. This has been demonstrated in uremic children treated with aluminum-containing antacids. The purpose of this study was to determine whether plasma aluminum levels were elevated in infants with normal renal function during prolonged aluminum-containing antacid use. Ten study infants (mean age = 5.8 months), who had been receiving antacids for at least 1 week, were compared with 16 control infants (mean age = 9.8 months) not receiving antacids. The study patients consumed 123 +/- 16 mg/kg per day (mean +/- SEM) of elemental aluminum for an average of 4.7 weeks. Their plasma aluminum level (37.2 +/- 7.13 micrograms/L) was significantly greater than that of the control group (4.13 +/- 0.66 micrograms/L) (P less than .005). It is concluded that plasma aluminum levels may become elevated in infants with normal renal function who are consuming high doses of aluminum-containing antacids. The safety of antacids containing aluminum should not be assumed and they should be used judiciously in infants, with careful monitoring of the aluminum dose and plasma level.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0031-4005
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
148-51
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1987526-Aluminum,
pubmed-meshheading:1987526-Antacids,
pubmed-meshheading:1987526-Body Weight,
pubmed-meshheading:1987526-Creatinine,
pubmed-meshheading:1987526-Drug Administration Schedule,
pubmed-meshheading:1987526-Female,
pubmed-meshheading:1987526-Gastroesophageal Reflux,
pubmed-meshheading:1987526-Humans,
pubmed-meshheading:1987526-Infant,
pubmed-meshheading:1987526-Infant, Newborn,
pubmed-meshheading:1987526-Kidney,
pubmed-meshheading:1987526-Male,
pubmed-meshheading:1987526-Regression Analysis
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Elevated plasma aluminum levels in normal infants receiving antacids containing aluminum.
|
| pubmed:affiliation |
Department of Pediatrics, Creighton University School of Medicine, Omaha.
|
| pubmed:publicationType |
Journal Article
|