| pubmed-article:19874716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19874716 | lifeskim:mentions | umls-concept:C0812258 | lld:lifeskim |
| pubmed-article:19874716 | lifeskim:mentions | umls-concept:C1257743 | lld:lifeskim |
| pubmed-article:19874716 | lifeskim:mentions | umls-concept:C1414069 | lld:lifeskim |
| pubmed-article:19874716 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:19874716 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19874716 | pubmed:dateCreated | 2009-10-30 | lld:pubmed |
| pubmed-article:19874716 | pubmed:abstractText | The E2F gene family appears to regulate the proliferation and differentiation of events that are required for adipogenesis. Pref-1 is a transmembrane protein that inhibits adipocyte differentiation in 3T3-L1 cells. In this study, we found that the expression of pref-1 is regulated by the transcription factor E2F1. The expression of pref-1 and E2F1 was strongly induced in preadipocytes and at the late differentiation stage. Using luciferase reporter assay, ChIP assay and EMSA, we found that the -211/-194 region of the pref-1 promoter is essential for the binding of E2F1 as well as E2F1-dependent transcriptional activation. Knockdown of E2F1 reduced both pref-1 promoter activity and the level of pref-1 mRNA. Taken together, our data suggest that transcriptional activation of pref-1 is stimulated by E2F1 protein in adipocytes. | lld:pubmed |
| pubmed-article:19874716 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19874716 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19874716 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19874716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19874716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19874716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19874716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19874716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19874716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19874716 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19874716 | pubmed:issn | 1976-6696 | lld:pubmed |
| pubmed-article:19874716 | pubmed:author | pubmed-author:MoonYang... | lld:pubmed |
| pubmed-article:19874716 | pubmed:author | pubmed-author:KimSang... | lld:pubmed |
| pubmed-article:19874716 | pubmed:author | pubmed-author:YunCheol-Heui... | lld:pubmed |
| pubmed-article:19874716 | pubmed:author | pubmed-author:ShenYan NanYN | lld:pubmed |
| pubmed-article:19874716 | pubmed:author | pubmed-author:KimYoon MoYM | lld:pubmed |
| pubmed-article:19874716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19874716 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:19874716 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:19874716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19874716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19874716 | pubmed:pagination | 691-6 | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
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| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:meshHeading | pubmed-meshheading:19874716... | lld:pubmed |
| pubmed-article:19874716 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19874716 | pubmed:articleTitle | Transcriptional activation of pref-1 by E2F1 in 3T3 L1 cells. | lld:pubmed |
| pubmed-article:19874716 | pubmed:affiliation | Department of Biology, Kyung Hee University, Seoul, Korea. | lld:pubmed |
| pubmed-article:19874716 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19874716 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:13386 | entrezgene:pubmed | pubmed-article:19874716 | lld:entrezgene |
| entrez-gene:13555 | entrezgene:pubmed | pubmed-article:19874716 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19874716 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19874716 | lld:entrezgene |
