Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-22
pubmed:abstractText
1. All inorganic perfusing solution for the heart of the lobster Homarus americanus, to allow prolonged normal beating (20 hours or more) must agree closely with the inorganic composition of the serum, which varies differentially with that of the environmental sea water. 2. All of the chief inorganic ions of the serum are necessary-Na, K, Ca, Mg, Cl, and SO(4); the critical numbers of the ions being 100, 3, 5, 2-3, 116, and 1-2 respectively. Absence of Mg and SO(4) will be tolerated for several hours. 3. The pH of the solution must agree with that of the serum within 0.2. 4. The osmotic pressure of the solution must agree with that of the serum within 15 per cent. 5. Beating of the heart will continue for several hours on improperly balanced solutions but changes in frequency, tone, or amplitude will occur. Hearts adapted to such solutions will show different responses to physical and chemical stimuli of the solution than those perfused on properly balanced solutions. 6. Arrest in systole is caused by isotonic NaCl, KCl, LiCl, and urea, and arrest in diastole by isotonic CaCl(2), MgCl(2), NaBr, NaI, MgSO(4), and glucose. 7. Lithium cannot replace sodium; neither can bromide or iodide replace chloride ions.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1295
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:dateRevised
2010-9-28
pubmed:year
1941
pubmed:articleTitle
A PERFUSING SOLUTION FOR THE LOBSTER (HOMARUS) HEART AND THE EFFECTS OF ITS CONSTITUENT IONS ON THE HEART.
pubmed:affiliation
Laboratories of Physiology, Rutgers University, New Brunswick, New Jersey, and the Mount Desert Island Biological Laboratory, Salsbury Cove, Maine.
pubmed:publicationType
Journal Article