Linked Life Data

19869681

Source:http://linkedlifedata.com/resource/pubmed/id/19869681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-22
pubmed:abstractText
R forms of Pneumococcus may be converted into S forms of the homologous Type. In addition to the methods previously reported,-(1) animal passage and (2) growth in anti-R sera,-conversion may be effected by the following procedures as employed by Griffith; (1) The subcutaneous injection, in white mice, of large amounts of living R organisms. (2) The subcutaneous injection, in white mice, of small amounts of living R organisms together with the heat-killed bacteria from large amounts of homologous S cultures. There are "varying degrees of constancy of the R variant"; but by these means it has been possible to effect conversion of all R forms selected. Attempts to cause a further "degradation" of R organisms by continued growth in homologous immune serum have been unsuccessful. Type II S and III S vaccines are equally effective in producing conversion when heated for 15' at 60 degrees C., or for 15' at 100 degrees C. Type I S vaccine, however, while effective in causing conversion when heated for 15' at 60 degrees C., apparently loses this property when heated for 15' at 100 degrees C. R vaccines, and vaccines of other organisms, when injected together with live R cultures, have always failed to produce conversion. The causes responsible for conversion under these experimental conditions are discussed and the possibility of the occurrence of a similar process under natural conditions in human beings is indicated.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-122
pubmed:dateRevised
2010-9-28
pubmed:year
1930
pubmed:articleTitle
THE TRANSFORMATION OF PNEUMOCOCCAL TYPES : I. THE CONVERSION OF R FORMS OF PNEUMOCOCCUS INTO S FORMS OF THE HOMOLOGOUS TYPE.
pubmed:affiliation
Hospital of The Rockefeller Institute for Medical Research.
pubmed:publicationType
Journal Article