Linked Life Data

1986636

Source:http://linkedlifedata.com/resource/pubmed/id/1986636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-2-8
pubmed:abstractText
A novel approach for increasing the duration of anesthesia after a single subarachnoid injection of a local anesthetic is presented. Tetracaine 1% 0.5 mg/kg was administered in 10% glucose or in lipid solution (iophendylate) in two groups of rabbits via catheters chronically implanted in the subarachnoid space. The pharmacologic effect was assessed by evaluation of the intensity and duration of the motor blockade according to a three-stage scale. Significant prolongation (447 +/- 13 min vs. 130 +/- 7 min, P less than 0.01) with a moderate decrease in the intensity of the motor blockade was observed with lipid solution as compared to the aqueous solution. This effect is attributed to the slow release of the agent from the lipid phase, which actually functions as a drug depot in the cerebrospinal fluid. The proposed method is suggested as an additional approach for the development of drug delivery system intended for prolongation of spinal anesthesia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Spinal anesthesia: significant prolongation of the pharmacologic effect of tetracaine with lipid solution of the agent.
pubmed:affiliation
Department of Anesthesiology, Rebecca Sieff Government Hospital, Safed, Israel.
pubmed:publicationType
Journal Article