| pubmed-article:19864379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19864379 | lifeskim:mentions | umls-concept:C1175743 | lld:lifeskim |
| pubmed-article:19864379 | lifeskim:mentions | umls-concept:C1478824 | lld:lifeskim |
| pubmed-article:19864379 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19864379 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:19864379 | lifeskim:mentions | umls-concept:C1422064 | lld:lifeskim |
| pubmed-article:19864379 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:19864379 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19864379 | pubmed:dateCreated | 2009-12-23 | lld:pubmed |
| pubmed-article:19864379 | pubmed:abstractText | The human coronaviruses (CoVs) severe acute respiratory syndrome (SARS)-CoV and NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that recombinant SARS-CoV spike protein (SARS-S) downregulates ACE2 expression and thereby promotes lung injury. Whether NL63-S exerts a similar activity is yet unknown. We found that recombinant SARS-S bound to ACE2 and induced ACE2 shedding with higher efficiency than NL63-S. Shedding most likely accounted for the previously observed ACE2 downregulation but was dispensable for viral replication. Finally, SARS-CoV but not NL63 replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS-CoV but not NL63 infection. | lld:pubmed |
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| pubmed-article:19864379 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19864379 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19864379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19864379 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19864379 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:PöhlmannStefa... | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:DrostenChrist... | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:SimmonsGraham... | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:HofmannHeikeH | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:WeberFriedema... | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:MuenchMarcus... | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:EichlerJuttaJ | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:HerzogPetraP | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:KuriThomasT | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:PfefferleSusa... | lld:pubmed |
| pubmed-article:19864379 | pubmed:author | pubmed-author:BertramStepha... | lld:pubmed |
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| pubmed-article:19864379 | pubmed:author | pubmed-author:SteffenImkeI | lld:pubmed |
| pubmed-article:19864379 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19864379 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:19864379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19864379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19864379 | pubmed:pagination | 1198-205 | lld:pubmed |
| pubmed-article:19864379 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19864379 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19864379 | pubmed:articleTitle | Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. | lld:pubmed |
| pubmed-article:19864379 | pubmed:affiliation | Institute of Virology, OE 5230, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. | lld:pubmed |
| pubmed-article:19864379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19864379 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19864379 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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