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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-12-23
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pubmed:abstractText |
The human coronaviruses (CoVs) severe acute respiratory syndrome (SARS)-CoV and NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that recombinant SARS-CoV spike protein (SARS-S) downregulates ACE2 expression and thereby promotes lung injury. Whether NL63-S exerts a similar activity is yet unknown. We found that recombinant SARS-S bound to ACE2 and induced ACE2 shedding with higher efficiency than NL63-S. Shedding most likely accounted for the previously observed ACE2 downregulation but was dispensable for viral replication. Finally, SARS-CoV but not NL63 replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS-CoV but not NL63 infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-14647384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-14766227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15073334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15141376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15141377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15194496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15221932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15358126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15648061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15655772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15660517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15686594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15827197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15897467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15909257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-15983030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-16001071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-16007097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-16102311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-16104827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-16306622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-17631932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-17897633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-17944272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-18022664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-18490652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-18818320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-18931070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-19027037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-19411314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-19461648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-3095925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-8028669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19864379-9499078
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:BertramStephanieS,
pubmed-author:DrostenChristianC,
pubmed-author:EichlerJuttaJ,
pubmed-author:GlowackaIlonaI,
pubmed-author:HerzogPetraP,
pubmed-author:HofmannHeikeH,
pubmed-author:KuriThomasT,
pubmed-author:MuenchMarcus OMO,
pubmed-author:PöhlmannStefanS,
pubmed-author:PfefferleSusanneS,
pubmed-author:SimmonsGrahamG,
pubmed-author:SteffenImkeI,
pubmed-author:WeberFriedemannF
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pubmed:issnType |
Electronic
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1198-205
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19864379-Animals,
pubmed-meshheading:19864379-Cell Line,
pubmed-meshheading:19864379-Cercopithecus aethiops,
pubmed-meshheading:19864379-Coronavirus,
pubmed-meshheading:19864379-Down-Regulation,
pubmed-meshheading:19864379-Humans,
pubmed-meshheading:19864379-Membrane Glycoproteins,
pubmed-meshheading:19864379-Peptidyl-Dipeptidase A,
pubmed-meshheading:19864379-SARS Virus,
pubmed-meshheading:19864379-Transfection,
pubmed-meshheading:19864379-Vero Cells,
pubmed-meshheading:19864379-Viral Envelope Proteins,
pubmed-meshheading:19864379-Virus Replication
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pubmed:year |
2010
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pubmed:articleTitle |
Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.
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pubmed:affiliation |
Institute of Virology, OE 5230, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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