Linked Life Data

19864076

Source:http://linkedlifedata.com/resource/pubmed/id/19864076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-1
pubmed:abstractText
Prostate cancer (CaP) is one of the most common types of cancer among men and the second leading cause of cancer-related death in western countries. The risk factors for CaP are age, race/ethnicity, family history and diet. It is interesting that epidemiologic evidence suggests a history of diabetes mellitus (DM) is related to a decreased CaP risk. The cause of this association remains largely unknown. DM is a group of metabolic diseases characterized by hyperglycemia and insulin resistance. It is commonly associated with microvascular complications including diabetic retinopathy, nephropathy and neuropathy. The typical histological changes of microvascular lesions are capillary basement membrane thickening, capillary occlusion and degeneration, eventually capillary dysfunction and organ ischemia. Therefore, we hypothesize that DM might induce local microvascular dysfunction and prostate ischemia, which prevent initiation and development of CaP. Currently, numerous studies showing effect of anti-angiogenesis therapy on CaP strongly support our hypothesis.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1532-2777
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
242-3
pubmed:dateRevised
2011-5-27
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Why does diabetes offer protective effects against prostate cancer? The possible role of its microvascular complications.
pubmed:affiliation
Department of Endocrinology and Metabolism, HuaShan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai, China.
pubmed:publicationType
Journal Article