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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-30
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pubmed:abstractText |
Four new indolosesquiterpenes, lecanindoles A-D (1-4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1-4 were elucidated from analysis of spectroscopic data. Compound 2 was reduced to give 4 and its isomer 5. Compound 4 was found to be a potent and selective progesterone receptor agonist with an EC50 of 1.1 +/- 0.4 nM in a cell-based luciferase reporter assay.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1520-6025
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1944-8
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pubmed:meshHeading |
pubmed-meshheading:19863083-Animals,
pubmed-meshheading:19863083-Cercopithecus aethiops,
pubmed-meshheading:19863083-Female,
pubmed-meshheading:19863083-Humans,
pubmed-meshheading:19863083-Hypocreales,
pubmed-meshheading:19863083-Indoles,
pubmed-meshheading:19863083-Luciferases,
pubmed-meshheading:19863083-Molecular Structure,
pubmed-meshheading:19863083-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:19863083-Progestins,
pubmed-meshheading:19863083-Receptors, Progesterone,
pubmed-meshheading:19863083-Sesquiterpenes
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pubmed:year |
2009
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pubmed:articleTitle |
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.
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pubmed:affiliation |
Chemical Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. rolld@wyeth.com
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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