Linked Life Data

19861351

Source:http://linkedlifedata.com/resource/pubmed/id/19861351

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-3-3
pubmed:abstractText
Considerable progress in our understanding of the role of the angiotensin II type 2 (AT(2)) receptor in the development of cardiac hypertrophy and coronary artery disease has been achieved using in vitro and in vivo animal models. Our understanding in humans, however, has been hindered by the lack of availability of specific AT(2) receptor agonists and antagonists suitable for human study. Nevertheless, an alternative approach involving genotyping humans for a functional polymorphism within the AT(2) receptor gene (-1332G/A) has been used in several association studies to elucidate the pathogenic role of the AT(2) receptor in cardiovascular disease. Both the A allele and the G allele have independently been associated with left ventricular remodelling. However, the methods of measuring left ventricular mass, sodium balance, age and degree of remodelling appear to influence the outcome. An association of carriers of the G allele and premature coronary artery disease has also been established, particularly in males presenting with stenotic atherosclerosis requiring revascularisation. At the molecular level, it remains unclear as to whether carriers of the G allele express more or fewer AT(2) receptors when compared to carriers of the A allele. Consequently, it is presently not possible to definitively interpret the role of the AT(2) receptor in human cardiovascular disease from these association studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1752-8976
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-85
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Angiotensin II type 2 receptor gene polymorphisms in cardiovascular disease.
pubmed:affiliation
Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds LS2 9JT, United Kingdom. A.J.Balmforth@leeds.ac.uk
pubmed:publicationType
Journal Article, Review