Source:http://linkedlifedata.com/resource/pubmed/id/19861093
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
The purpose of the present work was to study the dose-effect relationship of the antidepressant amitriptyline on inhibitory avoidance in male and female mice. Subjects received physiological saline or 2.5, 5, 10 or 20 mg/kg of amitriptyline hydrochloride 30 min before the training phase, and were subjected to the test phase 24 h later. Results showed a clear impairing effect of amitriptyline on inhibitory avoidance in both male and female mice, and that the effect is dose-dependent.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0214-9915
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
528-30
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pubmed:meshHeading |
pubmed-meshheading:19861093-Amitriptyline,
pubmed-meshheading:19861093-Animals,
pubmed-meshheading:19861093-Avoidance Learning,
pubmed-meshheading:19861093-Depression, Chemical,
pubmed-meshheading:19861093-Dose-Response Relationship, Drug,
pubmed-meshheading:19861093-Female,
pubmed-meshheading:19861093-Male,
pubmed-meshheading:19861093-Mice,
pubmed-meshheading:19861093-Random Allocation,
pubmed-meshheading:19861093-Reaction Time
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pubmed:year |
2009
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pubmed:articleTitle |
The effect of amitriptyline on inhibitory avoidance in mice is dose-dependent.
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pubmed:affiliation |
Facultad de Psicología, Universidad de Valencia, Spain. andres.parra@uv.es
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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