Linked Life Data

19857905

Source:http://linkedlifedata.com/resource/pubmed/id/19857905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2009-11-27
pubmed:abstractText
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine, and the functional TSLP receptor (TSLPR) consists of a common IL-7 receptor alpha chain (IL-7Ralpha) and TSLP-specific gamma receptor chain (TSLPR-gamma). It has been demonstrated that TSLP plays an important role in the Th2 bias and regulatory T cell expansion of immune response and tolerance. A successful pregnancy, especially in the early phase, demonstrates features of a Th2 immune response and requires CD4(+)Foxp3(+) regulatory T cell expansion. We have found recently that TSLP-instructed decidual dendritic cells (dDCs) promote decidual CD4(+) T cells to produce Th2-type cytokines including IL-10, which is believed to be a key player in maternal-fetal tolerance. Phenotypic analyses have shown that the expanded cells are mainly CD4(+) Th2 cells and Foxp3(+) regulatory T cells. Our findings show that trophoblasts secrete TSLP that is able to instruct the dDCs to induce CD4(+) Th2 cell and Foxp3(+) regulatory T cell differentiation in decidual CD4(+) T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-7603
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The regulatory role of thymic stromal lymphopoietin (TSLP) in maternal-fetal immune tolerance during early human pregnancy.
pubmed:affiliation
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, China. djli@shmu.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't