Source:http://linkedlifedata.com/resource/pubmed/id/19856477
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2009-11-2
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pubmed:abstractText |
The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1096-9071
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1999-2006
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pubmed:meshHeading |
pubmed-meshheading:19856477-Adolescent,
pubmed-meshheading:19856477-Adult,
pubmed-meshheading:19856477-Age Factors,
pubmed-meshheading:19856477-Aged,
pubmed-meshheading:19856477-Aged, 80 and over,
pubmed-meshheading:19856477-Antibodies, Viral,
pubmed-meshheading:19856477-Cross-Sectional Studies,
pubmed-meshheading:19856477-Female,
pubmed-meshheading:19856477-Geography,
pubmed-meshheading:19856477-HIV,
pubmed-meshheading:19856477-HIV Infections,
pubmed-meshheading:19856477-Hepatitis, Viral, Human,
pubmed-meshheading:19856477-Hepatitis B, Chronic,
pubmed-meshheading:19856477-Humans,
pubmed-meshheading:19856477-Italy,
pubmed-meshheading:19856477-Male,
pubmed-meshheading:19856477-Middle Aged,
pubmed-meshheading:19856477-Prevalence
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pubmed:year |
2009
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pubmed:articleTitle |
Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study.
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pubmed:affiliation |
Department of Infectious and Tropical Diseases, University La Sapienza, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Multicenter Study
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