Source:http://linkedlifedata.com/resource/pubmed/id/19854615
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-2-3
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| pubmed:abstractText |
Focal cortical dysplasias (FCDs) represent a prominent cause of pharmacologically intractable epilepsy. In FCD, the decrease of parvalbumin immunoreactive (PV+) inhibitory interneurons has been repeatedly documented. Here, we wanted to show whether another interneuronal population, the calretinin immunoreactive (CR+) neurons, exhibits any change in human FCD. We also investigated samples of morphologically normal temporal neocortex resected together with sclerotic hippocampus (nHSTN), where decrease of PV+ interneurons was previously documented as well. Brain tissue from 24 patients surgically treated for pharmacoresistant epilepsy was examined. Calretinin immunoreactivity was qualitatively evaluated and the density of CR+ neuronal profiles was quantified. As a control, post-mortem acquired neocortical samples of nine patients without any brain affecting disease were used. CR+ neurons were located predominantly in superficial cortical layers both in controls and pathological samples. Similarly, the morphology of CR+ neurons was unaffected in pathological samples. The overall density of CR+ neurons was significantly decreased in FCD type I (to approximately 70% of control values) and even more in FCD type II (to approximately 50% of controls). In nHSTN, no change compared to controls was found in CR+ neuronal density. Our results may contribute to the better understanding of the role of individual interneuronal populations in epileptogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1872-6844
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| pubmed:author | |
| pubmed:copyrightInfo |
2009 Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
88
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
76-86
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| pubmed:meshHeading |
pubmed-meshheading:19854615-Adolescent,
pubmed-meshheading:19854615-Adult,
pubmed-meshheading:19854615-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:19854615-Cerebral Cortex,
pubmed-meshheading:19854615-Child,
pubmed-meshheading:19854615-Child, Preschool,
pubmed-meshheading:19854615-Electroencephalography,
pubmed-meshheading:19854615-Epilepsy,
pubmed-meshheading:19854615-Female,
pubmed-meshheading:19854615-Fluorodeoxyglucose F18,
pubmed-meshheading:19854615-Hippocampus,
pubmed-meshheading:19854615-Humans,
pubmed-meshheading:19854615-Interneurons,
pubmed-meshheading:19854615-Magnetic Resonance Imaging,
pubmed-meshheading:19854615-Male,
pubmed-meshheading:19854615-Malformations of Cortical Development,
pubmed-meshheading:19854615-Middle Aged,
pubmed-meshheading:19854615-Parvalbumins,
pubmed-meshheading:19854615-Positron-Emission Tomography,
pubmed-meshheading:19854615-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex.
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| pubmed:affiliation |
Department of Anatomy, Charles University in Prague, Czech Republic. filipbarinka@yahoo.co.uk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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