pubmed:abstractText |
To investigate whether carcinoma in situ (CIS) lesion could be considered a surrogate marker of urothelium genetic instability and field carcinogenesis or not, we evaluated DNA content, p53 overexpression, and proliferative index (Ki-67 expression) in primary tumor, in tumor-adjacent mucosa, and distant urothelial mucosa with and without presence of CIS.
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pubmed:affiliation |
Department of Immunology, Portuguese Institute of Oncology, Porto, and Health School of University Fernando Pessoa, Porto, Portugal. palmeira.ca@gmail.com
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