Linked Life Data

19845851

Source:http://linkedlifedata.com/resource/pubmed/id/19845851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-12-22
pubmed:abstractText
The mammalian target of rapamycin (mTOR), which phosphorylates p70S6K and 4EBP1 and activates the protein translation process, is upregulated in cancers and its activation may be involved in cancer development. Aims: In this study, we investigated the tumour-suppressive effects of rapamycin and its new analogue CCI-779 on hepatocellular carcinoma (HCC).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1478-3231
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-75
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19845851-Animals, pubmed-meshheading:19845851-Antibiotics, Antineoplastic, pubmed-meshheading:19845851-Carcinoma, Hepatocellular, pubmed-meshheading:19845851-Cell Count, pubmed-meshheading:19845851-Cell Line, Transformed, pubmed-meshheading:19845851-Cell Line, Tumor, pubmed-meshheading:19845851-Cell Proliferation, pubmed-meshheading:19845851-Drug Screening Assays, Antitumor, pubmed-meshheading:19845851-Female, pubmed-meshheading:19845851-Humans, pubmed-meshheading:19845851-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:19845851-Liver Neoplasms, pubmed-meshheading:19845851-Male, pubmed-meshheading:19845851-Mice, pubmed-meshheading:19845851-Mice, Inbred BALB C, pubmed-meshheading:19845851-Mice, Nude, pubmed-meshheading:19845851-Protein-Serine-Threonine Kinases, pubmed-meshheading:19845851-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19845851-Signal Transduction, pubmed-meshheading:19845851-Sirolimus, pubmed-meshheading:19845851-TOR Serine-Threonine Kinases
pubmed:year
2010
pubmed:articleTitle
Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma.
pubmed:affiliation
Liver Cancer and Hepatitis Research Laboratory, Department of Pathology, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't