Linked Life Data

19839814

Source:http://linkedlifedata.com/resource/pubmed/id/19839814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-10-20
pubmed:abstractText
The rapidly growing applications of nanomagnets in magnetic drug delivery and separation in clinical diagnostics require strong and reliable magnetic vehicles. Strength conveys rapid processing, high delivery/targeting yield and rapid results when used in clinics. Reliability enables recycling of nanomagnets, regulatory-conforming drug formulations and efficient use of (expensive) antibodies in diagnostics, combined with reduced leaching (reagent loss). The present work illustrates how metal-based nanomagnets provide a two-three-times stronger magnetic particle than conventional magnetite-based materials. Ligands, antibodies or drugs can be anchored to such carbon/metal core/shell nanomagnets over covalent, hydrolysis-resistant carbon-carbon bonds. This linker chemistry resists strong acids, sterilization and prolonged storage or aggressive treatment. As dispersions, functional nanomagnets rapidly scan liquids/tissue by Brownian diffusion, capture/deliver/react at a target and are efficiently recollected after use. Metal iron-based, carbon-coated nanomagnets consist of particularly well-accepted materials and now open stable nanomagnets to a broad range of fascinating separation problems in biomedical research.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1748-6963
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
787-98
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
High-strength metal nanomagnets for diagnostics and medicine: carbon shells allow long-term stability and reliable linker chemistry.
pubmed:affiliation
Institute for Chemical & Bioengineering, Department of Chemistry & Applied Biosciences, ETH Zurich, Zurich, Switzerland.
pubmed:publicationType
Journal Article, Review