Linked Life Data

1983814

Source:http://linkedlifedata.com/resource/pubmed/id/1983814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-1-10
pubmed:abstractText
The steps involved in iron absorption are poorly understood. Although transferrin and ferritin are water soluble, most radioiron in gut homogenates after an intraluminal dose of radioiron is recovered in water-insoluble precipitates. Most radioiron in the precipitates was insoluble in detergents and organic solvents and was characterized as mucins. These isolates bound iron in vitro with a Kd of 9.09 x 10(-5). Similar iron binding was observed with commercial mucins. Iron binding to mucin occurred at acid pH and maintained the iron available for absorption with alkalinization. Similar pH-dependent binding to mucin was observed with zinc, cobalt, and lead. Iron competitively inhibited binding of these metals to mucin. However, iron chelates of ascorbate, fructose, and histidine donated iron to mucin at neutral pH. These data provided a role for gastric HCl and intestinal mucin in absorption of iron and metal cations and partial explanation of the competition for absorption between certain metals from the gut lumen. It is postulated that intestinal mucin delivers inorganic iron to intestinal absorptive cells in an acceptable form for absorption.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-36
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
A role for mucin in the absorption of inorganic iron and other metal cations. A study in rats.
pubmed:affiliation
Department of Medicine, University of South Alabama, Mobile.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.