Linked Life Data

19827315

Source:http://linkedlifedata.com/resource/pubmed/id/19827315

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-10-15
pubmed:abstractText
Based on the results of our investigation of patients with anxious depression under the treatment with serotonergic antidepressants with different mechanism of action on serotonin reuptake we, the first time in the literature, propose the hypothesis about neurochemical mechanism of tianeptine action. According to this hypothesis tianeptine not only activates serotonin reuptake into the synaptic ending but also activates its release from the ending into the synaptic cleft thus accelerating serotonin turnover rate in the synapse. Proposed mechanism mainly refers the first, acute phase of its action directed to the normalization of serotonergic neurotransmission.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1419-8711
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Antidepressant action of tianeptine is connected with acceleration of serotonin turnover in the synapse: a hypothesis.
pubmed:affiliation
Department of Brain Pathology, Research Institute of Psychiatry, Moscow. uzbekovmg@mtu-net.ru
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't