19825886

Source:http://linkedlifedata.com/resource/pubmed/id/19825886

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0027651, umls-concept:C0030705, umls-concept:C0031327, umls-concept:C0036043, umls-concept:C0086960, umls-concept:C0205179, umls-concept:C0205208, umls-concept:C0205267, umls-concept:C0442027, umls-concept:C0549178, umls-concept:C0851347, umls-concept:C0919418, umls-concept:C1152568, umls-concept:C1332739, umls-concept:C1511576, umls-concept:C1521801, umls-concept:C1541359, umls-concept:C1554217
pubmed:issue	4
pubmed:dateCreated	2010-3-26
pubmed:abstractText	AZD5438 is an orally bioavailable inhibitor of cyclin E-cdk2, cyclin A-cdk2 and cyclin B-cdk1 complexes. Three phase I studies assessed the clinical safety, tolerability, pharmacokinetics and pharmacodynamics of AZD5438 when administered in different dosing schedules.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P20 CA90578, http://linkedlifedata.com/resource/pubmed/grant/R01 CA090687-10, http://linkedlifedata.com/resource/pubmed/grant/R01 CA90687
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9007735
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/AZD5438, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Biomarkers, Pharmacological, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1569-8041
pubmed:author	pubmed-author:AmakyeD DDD, pubmed-author:BossD SDS, pubmed-author:CalvertHH, pubmed-author:CarvajalR DRD, pubmed-author:ChirieacL RLR, pubmed-author:DansonSS, pubmed-author:MiddletonM RMR, pubmed-author:MidgleyR SRS, pubmed-author:MorrisCC, pubmed-author:PlummerRR, pubmed-author:RansonMM, pubmed-author:SchellensJ H MJH, pubmed-author:SchwartzG KGK, pubmed-author:ShapiroG IGI, pubmed-author:SwaislandHH
pubmed:issnType	Electronic
pubmed:volume	21
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	884-94
pubmed:dateRevised	2011-7-27
pubmed:meshHeading	pubmed-meshheading:19825886-Humans, pubmed-meshheading:19825886-Neoplasms, pubmed-meshheading:19825886-Aged, pubmed-meshheading:19825886-Aged, 80 and over, pubmed-meshheading:19825886-Imidazoles, pubmed-meshheading:19825886-Pyrimidines, pubmed-meshheading:19825886-Female, pubmed-meshheading:19825886-Male, pubmed-meshheading:19825886-Treatment Outcome, pubmed-meshheading:19825886-Adult, pubmed-meshheading:19825886-Antineoplastic Agents, pubmed-meshheading:19825886-Administration, Oral, pubmed-meshheading:19825886-Dose-Response Relationship, Drug, pubmed-meshheading:19825886-Disease Progression, pubmed-meshheading:19825886-Drug Administration Schedule, pubmed-meshheading:19825886-Cohort Studies, pubmed-meshheading:19825886-Protein Kinase Inhibitors, pubmed-meshheading:19825886-Cyclin-Dependent Kinases

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