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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Sugar consumption has increased markedly over the last few decades and parallels the dramatic increase in overweight and obesity. Data obtained from animal studies suggest that the intestinal serotonergic system and herein particularly the serotonin receptor 3 (5-HT3R) may be involved in sugar detection and short-term control of food intake. Using a mouse model, we tested the hypothesis that blocking 5-HT3R prevents the development of sugar-induced obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1476-5497
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1339-47
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pubmed:meshHeading |
pubmed-meshheading:19823183-Animals,
pubmed-meshheading:19823183-Body Weight,
pubmed-meshheading:19823183-Gastrointestinal Motility,
pubmed-meshheading:19823183-Glucose,
pubmed-meshheading:19823183-Glucose Transport Proteins, Facilitative,
pubmed-meshheading:19823183-Indoles,
pubmed-meshheading:19823183-Mice,
pubmed-meshheading:19823183-Mice, Inbred C57BL,
pubmed-meshheading:19823183-Obesity,
pubmed-meshheading:19823183-RNA, Messenger,
pubmed-meshheading:19823183-Serotonin Antagonists,
pubmed-meshheading:19823183-Weight Gain
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pubmed:year |
2009
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pubmed:articleTitle |
Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice.
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pubmed:affiliation |
Department of Nutritional Medicine (180a), University of Hohenheim, Stuttgart, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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