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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2009-11-2
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pubmed:abstractText |
Manganese superoxide dismutase (MnSOD) is vital to the protection of mitochondria and cells against oxidative stress. Earlier, we demonstrated that catalytically active homo-tetramer of MnSOD can be stabilized by oxidative cross-linking. Here we report that this effect may be translated into increased radioresistance of mouse embryonic cells (MECs) by pre-exposure to oxidative stress. Pre-treatment of MECs with antimycin A, rotenone or H(2)O(2) increased their survival after irradiation. Using MnSOD siRNA, we show that MECs with decreased MnSOD levels displayed a lowered ability to preconditioning. Thus oxidative preconditioning may be used for targeted regulation of MnSOD.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/HL70755,
http://linkedlifedata.com/resource/pubmed/grant/NS061817,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070755-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070755-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070755-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070755-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070755-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL070755-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS061817-02,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI068021-010002,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI068021-020002,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI068021-030002,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI068021-040002,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI068021-050002,
http://linkedlifedata.com/resource/pubmed/grant/U19-A1068021-01
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
583
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3437-42
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19822147-Animals,
pubmed-meshheading:19822147-Antimycin A,
pubmed-meshheading:19822147-Cell Death,
pubmed-meshheading:19822147-Electron Transport Complex I,
pubmed-meshheading:19822147-Electron Transport Complex III,
pubmed-meshheading:19822147-Embryo, Mammalian,
pubmed-meshheading:19822147-Mice,
pubmed-meshheading:19822147-Oxidative Stress,
pubmed-meshheading:19822147-Reactive Oxygen Species,
pubmed-meshheading:19822147-Rotenone,
pubmed-meshheading:19822147-Superoxide Dismutase,
pubmed-meshheading:19822147-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase.
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pubmed:affiliation |
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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