Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-3-25
pubmed:abstractText
We have investigated the degree of synteny between the long arm (q) of human chromosome 2 and the proximal portion of mouse chromosome 1. To define the limits of synteny, we have determined whether mouse homologs of seven human genes mapping to chromosome 2q cosegregated with anchor loci on mouse chromosome 1. The loci investigated were NEB/Neb, ELN/Eln, COL3A1/Col3a1, CRYG/Len-2, FN1/Fn-1, VIL/Vil, and COL6A3/Col6a3. Ren-1,2 and Acrg were included as two proximal mouse chromosome 1 anchor loci. The segregation of restriction fragment length polymorphisms at these loci was analyzed in the progeny of Mus spretus x C57BL/6J hybrids backcrossed to the C57BL/6J inbred strain. We found that five of the structural protein loci and the two anchor loci form a linkage group on proximal murine chromosome 1. The proposed gene order of this group of linked markers is centromere - Col3a1 - Len-2-Fn-1-Vil-Acrg-Col6a3-Ren1,2. Neb and Eln are linked neither to each other nor to any other marker on proximal mouse chromosome 1. Therefore, the mouse loci Col3a1 and Col6a3 are identified as flanking markers of the linkage group of structural protein loci. The estimated genetic map distances are Col3a1-13.3 cM-Len-2-3.4 cM-Fn-1-3.8 cM-Vil-9.6 cM-Acrg-2.1 cM-Col6a3-18.3 cM-Ren1,2. The available map information for human chromosome 2q markers and mouse chromosome 1 markers presented here tentatively identifies Col3a1 and Col6a3 as the border markers that define the limits of the syntenic chromosome segment. The order of mouse genes on chromosome 1 and their human homologs on chromosome 2q also appears to be conserved, suggesting that mapping of murine genes on the conserved segment may be useful to predict gene order in man.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:geneSymbol
Acrg, COL3A1, COL6A3, CRYG, ELN, FN1, Fn-1, Len-2, NEB, Ren-1,2, VIL
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
477-86
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:1981051-Animals, pubmed-meshheading:1981051-Chromosome Mapping, pubmed-meshheading:1981051-Chromosomes, Human, Pair 2, pubmed-meshheading:1981051-Genes, pubmed-meshheading:1981051-Genetic Linkage, pubmed-meshheading:1981051-Genetic Markers, pubmed-meshheading:1981051-Humans, pubmed-meshheading:1981051-Mice, pubmed-meshheading:1981051-Mice, Inbred C57BL, pubmed-meshheading:1981051-Multigene Family, pubmed-meshheading:1981051-Muridae, pubmed-meshheading:1981051-Phylogeny, pubmed-meshheading:1981051-Polymorphism, Restriction Fragment Length, pubmed-meshheading:1981051-Proteins, pubmed-meshheading:1981051-Recombination, Genetic, pubmed-meshheading:1981051-Restriction Mapping, pubmed-meshheading:1981051-Sequence Homology, Nucleic Acid, pubmed-meshheading:1981051-Species Specificity
pubmed:year
1990
pubmed:articleTitle
Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q.
pubmed:affiliation
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't