Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-10-27
pubmed:abstractText
The mechanism responsible for hepatitis B virus (HBV) exacerbation during chemotherapy and radiotherapy remains unknown. We investigated whether the activation of DNA repair pathways influences HBV replication. The upregulation of the promyelocytic leukemia (PML) protein and its associated PML nuclear body (PML-NB) by chemotherapy and irradiation-induced DNA repair signaling correlated with the upregulation of HBV pregenomic transcription, HBV-core expression, and HBV DNA replication. The HBV-core protein and HBV DNA localized to PML-NBs, where they associated with PML and histone deacetylase 1 (HDAC1). Chemotherapy and radiotherapy affected the interactions between PML, HBV-core, and HDAC1. The enhanced protein-protein interaction between PML and HBV-core inhibited PML-mediated apoptosis and decreased PML-associated HDAC activity. The reversal of HDAC-mediated repression on the HBV covalently closed circular DNA basal core promoter resulted in the amplification of HBV-core and pregenomic expression. These results suggest that PML in PML-NBs links the DNA damage response with HBV replication and may cooperate with HBV-core and HDAC1 on the HBV covalently closed circular DNA basal core promoter to form a positive feedback loop for HBV exacerbation during chemotherapy and radiotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1557-3125
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1672-85
pubmed:meshHeading
pubmed-meshheading:19808906-Cell Line, Tumor, pubmed-meshheading:19808906-Cell Nucleus, pubmed-meshheading:19808906-DNA, Circular, pubmed-meshheading:19808906-DNA, Viral, pubmed-meshheading:19808906-DNA Repair, pubmed-meshheading:19808906-Drug Therapy, pubmed-meshheading:19808906-Feedback, Physiological, pubmed-meshheading:19808906-Hepatitis B, pubmed-meshheading:19808906-Hepatitis B virus, pubmed-meshheading:19808906-Histone Deacetylase 1, pubmed-meshheading:19808906-Humans, pubmed-meshheading:19808906-Nuclear Proteins, pubmed-meshheading:19808906-Promoter Regions, Genetic, pubmed-meshheading:19808906-Radiotherapy, pubmed-meshheading:19808906-Transcription Factors, pubmed-meshheading:19808906-Transcriptional Activation, pubmed-meshheading:19808906-Tumor Suppressor Proteins, pubmed-meshheading:19808906-Viral Core Proteins, pubmed-meshheading:19808906-Virus Replication
pubmed:year
2009
pubmed:articleTitle
Promyelocytic leukemia nuclear bodies link the DNA damage repair pathway with hepatitis B virus replication: implications for hepatitis B virus exacerbation during chemotherapy and radiotherapy.
pubmed:affiliation
Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan. ylchung@kfsyscc.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't