Source:http://linkedlifedata.com/resource/pubmed/id/19796813
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-2-22
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| pubmed:abstractText |
The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). In the mouse, however, loss of Ikaros is primarily associated with T-ALL development. Whether Ikaros is also implicated in human T-ALL remains unclear. We studied Ikaros in 25 human T-ALL samples from diverse molecular subtypes at the mRNA, protein, sequence and genomic copy number level. We found that Ikaros was abnormal in only one sample: one allele was lost by genomic deletion, while proteins generated from the remaining allele were delocalized and concentrated at a single cytoplasmic structure. Thus, inactivation of Ikaros by deletion or mutation is rare in human T-ALL.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1873-5835
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
34
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
426-9
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| pubmed:meshHeading |
pubmed-meshheading:19796813-Adolescent,
pubmed-meshheading:19796813-Adult,
pubmed-meshheading:19796813-Child,
pubmed-meshheading:19796813-Child, Preschool,
pubmed-meshheading:19796813-Cohort Studies,
pubmed-meshheading:19796813-Comparative Genomic Hybridization,
pubmed-meshheading:19796813-Gene Deletion,
pubmed-meshheading:19796813-Gene Expression Regulation, Leukemic,
pubmed-meshheading:19796813-Gene Silencing,
pubmed-meshheading:19796813-Humans,
pubmed-meshheading:19796813-Ikaros Transcription Factor,
pubmed-meshheading:19796813-Infant,
pubmed-meshheading:19796813-Jurkat Cells,
pubmed-meshheading:19796813-Middle Aged,
pubmed-meshheading:19796813-Mutation,
pubmed-meshheading:19796813-Precursor T-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19796813-Protein Isoforms,
pubmed-meshheading:19796813-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Genetic inactivation of Ikaros is a rare event in human T-ALL.
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| pubmed:affiliation |
Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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