19796053

Source:http://linkedlifedata.com/resource/pubmed/id/19796053

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0024554, umls-concept:C0031640, umls-concept:C0185117, umls-concept:C0205245, umls-concept:C0332307, umls-concept:C0441655, umls-concept:C1880022, umls-concept:C2328796, umls-concept:C2911684
pubmed:issue	1 Pt 1
pubmed:dateCreated	2010-1-22
pubmed:abstractText	Phosphodiesterase type 5 (PDE5) inhibitors ameliorate low urinary tract (LUT) symptoms in men with ED and symptomatic benign prostatic hyperplasia (BPH). PDE5 is highly expressed in rat and human bladder, where it regulates cyclic guanosine monophosphate (cGMP) degradation, muscle tone, and proliferation.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101230693
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/BAY 41-8543, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide..., http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Morpholines, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors, http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Sulfones, http://linkedlifedata.com/resource/pubmed/chemical/Triazines, http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents, http://linkedlifedata.com/resource/pubmed/chemical/vardenafil
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	1743-6109
pubmed:author	pubmed-author:ChavalmaneAravindaA, pubmed-author:De VitaGiuliaG, pubmed-author:FRYW EWE, pubmed-author:FibbiBenedettaB, pubmed-author:FilippiSandraS, pubmed-author:GacciMauroM, pubmed-author:MariniMircaM, pubmed-author:MorelliAnnamariaA, pubmed-author:SandnerPeterP, pubmed-author:VannelliGabriella BarbaraGB, pubmed-author:VignozziLindaL
pubmed:issnType	Electronic
pubmed:volume	7
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	59-69
pubmed:meshHeading	pubmed-meshheading:19796053-Aged, pubmed-meshheading:19796053-Cell Division, pubmed-meshheading:19796053-Cyclic Nucleotide Phosphodiesterases, Type 5, pubmed-meshheading:19796053-Dose-Response Relationship, Drug, pubmed-meshheading:19796053-Drug Synergism, pubmed-meshheading:19796053-Gene Expression, pubmed-meshheading:19796053-Humans, pubmed-meshheading:19796053-Imidazoles, pubmed-meshheading:19796053-Male, pubmed-meshheading:19796053-Morpholines, pubmed-meshheading:19796053-Muscle, Smooth, pubmed-meshheading:19796053-Nitric Oxide Donors, pubmed-meshheading:19796053-Nitroprusside, pubmed-meshheading:19796053-Piperazines, pubmed-meshheading:19796053-Prostate, pubmed-meshheading:19796053-Prostatic Hyperplasia, pubmed-meshheading:19796053-Pyrimidines, pubmed-meshheading:19796053-RNA, Messenger, pubmed-meshheading:19796053-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19796053-Sulfones, pubmed-meshheading:19796053-Triazines, pubmed-meshheading:19796053-Urethra, pubmed-meshheading:19796053-Urinary Bladder, pubmed-meshheading:19796053-Vasodilator Agents
pubmed:year	2010
pubmed:articleTitle	Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract.
pubmed:affiliation	Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy. m.maggi@dfc.unifi.it
pubmed:publicationType	Journal Article