Linked Life Data

19795175

Source:http://linkedlifedata.com/resource/pubmed/id/19795175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-24
pubmed:abstractText
Catechol-O-methyl transferase (COMT) is a pivotal regulator of brain dopamine function with a region-specific role. COMT is important in dopamine elimination in the prefrontal cortex, whereas dopamine reuptake is the main mechanism for synaptic removal of dopamine in the striatum. We studied whether the functional COMT gene polymorphism (Val158Met) associates with altered dopamine D2 receptor binding characteristics in vivo hypothesizing an effect in the cortex but not in the striatum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1860-2002
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
192-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo.
pubmed:affiliation
Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't