Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-25
pubmed:abstractText
Anxiety arising during pain expectancy can modulate the subjective experience of pain. However, individuals differ in their sensitivity to pain expectancy. The amygdale and hippocampus were proposed to mediate the behavioral response to aversive stimuli. However, their differential role in mediating anxiety-related individual differences is not clear. Using fMRI, we investigated brain activity during expectancy to cued or uncued thermal pain applied to the wrist. Following each stimulation participants rated the intensity of the painful experience. Activations in the amygdala and hippocampus were examined with respect to individual differences in harm avoidance (HA) personality trait, and individual sensitivity to expectancy, (i.e. response to cued vs. uncued painful stimuli). Only half of the subjects reported on cued pain as being more painful than uncued pain. In addition, we found a different activation profile for the amygdala and hippocampus during pain expectancy and experience. The amygdala was more active during expectancy and this activity was correlated with HA scores. The hippocampal activity was equally increased during both pain expectancy and experience, and correlated with the individual's sensitivity to expectancy. Our findings suggest that the amygdala supports an innate tendency to approach or avoid pain as reflected in HA trait, whereas the hippocampus mediates the effect of context possibly via appraisal of the stimulus value.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1097-0193
pubmed:author
pubmed:copyrightInfo
(c) 2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
326-38
pubmed:meshHeading
pubmed-meshheading:19790170-Adult, pubmed-meshheading:19790170-Amygdala, pubmed-meshheading:19790170-Anxiety, pubmed-meshheading:19790170-Brain, pubmed-meshheading:19790170-Brain Mapping, pubmed-meshheading:19790170-Cues, pubmed-meshheading:19790170-Female, pubmed-meshheading:19790170-Hippocampus, pubmed-meshheading:19790170-Hot Temperature, pubmed-meshheading:19790170-Humans, pubmed-meshheading:19790170-Magnetic Resonance Imaging, pubmed-meshheading:19790170-Male, pubmed-meshheading:19790170-Mental Processes, pubmed-meshheading:19790170-Pain, pubmed-meshheading:19790170-Pain Measurement, pubmed-meshheading:19790170-Personality, pubmed-meshheading:19790170-Physical Stimulation, pubmed-meshheading:19790170-Questionnaires, pubmed-meshheading:19790170-Wrist, pubmed-meshheading:19790170-Young Adult
pubmed:year
2010
pubmed:articleTitle
Individual sensitivity to pain expectancy is related to differential activation of the hippocampus and amygdala.
pubmed:affiliation
Department of Psychology, University of Haifa, Mount Carmel, Haifa, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't