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rdf:type |
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lifeskim:mentions |
umls-concept:C0005768,
umls-concept:C0006142,
umls-concept:C0006826,
umls-concept:C0026882,
umls-concept:C0034897,
umls-concept:C0087111,
umls-concept:C0150369,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0936012,
umls-concept:C1510438,
umls-concept:C1519316
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-30
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pubmed:abstractText |
Tumor DNA has been shown to be present both in circulating tumor cells in blood and as fragments in the plasma of metastatic cancer patients. The identification of ultra-rare tumor-specific mutations in blood would be the ultimate marker to measure efficacy of cancer therapy and/or early recurrence. Herein we present a method for detecting microinsertions/deletions/indels (MIDIs) at ultra-high analytical selectivity. MIDIs comprise about 15% of mutations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-11424181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-11788724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-12504766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-14605056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-14740499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-15108273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-15643612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-16231326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-16432518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-16708764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-16987840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17041903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17108085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17301845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17322893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17429853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17589521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17659080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-17785543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-18164685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-18372921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-18670422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-2296286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-2340178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-2716852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-7847369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-8199598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-8673103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-9009845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19789704-9814434
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e7220
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pubmed:meshHeading |
pubmed-meshheading:19789704-Animals,
pubmed-meshheading:19789704-Breast Neoplasms,
pubmed-meshheading:19789704-DNA,
pubmed-meshheading:19789704-DNA Mutational Analysis,
pubmed-meshheading:19789704-DNA Primers,
pubmed-meshheading:19789704-Female,
pubmed-meshheading:19789704-Humans,
pubmed-meshheading:19789704-Neoplasm Metastasis,
pubmed-meshheading:19789704-Neoplasms,
pubmed-meshheading:19789704-Neoplastic Cells, Circulating,
pubmed-meshheading:19789704-Phosphorylation,
pubmed-meshheading:19789704-Rats,
pubmed-meshheading:19789704-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19789704-Recurrence,
pubmed-meshheading:19789704-Sensitivity and Specificity,
pubmed-meshheading:19789704-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: monitoring of therapy or recurrence in non-metastatic breast cancer.
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pubmed:affiliation |
Department of Molecular Genetics, City of Hope National Medical Center, Duarte, California, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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