Linked Life Data

1978850

Source:http://linkedlifedata.com/resource/pubmed/id/1978850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-1-10
pubmed:abstractText
The induction of chromosome aberrations by X-rays was investigated in synchronized quiescent and proliferating CHO-K1 cells. Kinetics of chromosome lesion repair was studied using the method of fractionated irradiation. In both cell types the time-course of repair during fractionation intervals followed first-order kinetics. Comparison with kinetic data reported on DNA double-strand break repair supports the hypothesis that DNA double-strand breaks are the lesions underlying chromosome aberration formation. Quiescent CHO cells showed higher aberration yields than proliferating cells, and chromosome lesion repair was faster in quiescent cells. This correlation can be interpreted in terms of a higher degree of repair synchronism during pairwise lesion interaction. The effect of delayed plating on aberration induction was studied in quiescent cells. The time-course of repair active during the delayed plating interval followed first-order kinetics. The kinetics observed in delayed plating experiments is slower than the repair kinetics observed in fractionation experiments, suggesting the involvement of two different processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0955-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1009-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Kinetics of chromosome lesion repair in synchronized quiescent and proliferating CHO cells.
pubmed:affiliation
Institute of Medical Physics and Biophysics, University of Göttingen, FRG.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't