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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
Histidine-rich glycoprotein (HRG) is a heparin-binding glycoprotein present in plasma at 100microg/ml. A recent study revealed that HRG suppressed heparin-dependent basic fibroblast growth factor (bFGF)-induced angiogenesis. Additionally, we reported that high mobility group box 1 (HMGB1) in complex with heparin induces angiogenesis; therefore, we examined the effect of HRG on heparin-dependent HMGB1-induced angiogenesis in the present study. HRG completely inhibited angiogenesis induced by HMGB1 in complex with heparin. HRG inhibited the diffusion of a complex of HMGB1 with heparin from matrigel into surrounding tissue. HRG also competed with HMGB1 for heparin binding in vitro. Moreover, HRG inhibited heparin-dependent vascular endothelial growth factor-A(165) (VEGF-A(165))-induced angiogenesis. These results strongly suggested that HRG might be an inhibitor of angiogenesis induced by growth factors with heparin binding activity and that HRG may be a potential drug for angiogenic diseases, including tumor growth.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/HMGB1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/histidine-rich proteins,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1879-0712
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
623
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-95
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pubmed:meshHeading |
pubmed-meshheading:19786011-Angiogenesis Inhibitors,
pubmed-meshheading:19786011-Angiogenic Proteins,
pubmed-meshheading:19786011-Animals,
pubmed-meshheading:19786011-Binding, Competitive,
pubmed-meshheading:19786011-Biocompatible Materials,
pubmed-meshheading:19786011-Collagen,
pubmed-meshheading:19786011-Drug Combinations,
pubmed-meshheading:19786011-Gene Expression Regulation,
pubmed-meshheading:19786011-HMGB1 Protein,
pubmed-meshheading:19786011-Heparin,
pubmed-meshheading:19786011-Implants, Experimental,
pubmed-meshheading:19786011-Laminin,
pubmed-meshheading:19786011-Male,
pubmed-meshheading:19786011-Mice,
pubmed-meshheading:19786011-Mice, Inbred C57BL,
pubmed-meshheading:19786011-Neovascularization, Pathologic,
pubmed-meshheading:19786011-Protein Binding,
pubmed-meshheading:19786011-Proteins,
pubmed-meshheading:19786011-Proteoglycans,
pubmed-meshheading:19786011-RNA, Messenger,
pubmed-meshheading:19786011-Time Factors,
pubmed-meshheading:19786011-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19786011-Vascular Endothelial Growth Factor A
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pubmed:year |
2009
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pubmed:articleTitle |
Histidine-rich glycoprotein inhibited high mobility group box 1 in complex with heparin-induced angiogenesis in matrigel plug assay.
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pubmed:affiliation |
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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