Linked Life Data

1978315

Source:http://linkedlifedata.com/resource/pubmed/id/1978315

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-12-19
pubmed:abstractText
We studied the effect of a primed i.v. infusion of somatostatin (100 micrograms as a bolus, 0.5 micrograms x kg-1 x min-1) on pancreatic exocrine secretion in response to electrical stimulation of the vagus nerves and intra-arterial infusions of acetylcholine (0.5 mg x min-1) in anesthetized pigs (17-22 kg). In control experiments, vagus stimulation and acetylcholine increased protein secretion 31- to 80-fold and 106-fold, respectively. Somatostatin inhibited the response to vagus stimulation by more than 90%, whereas the response to acetylcholine remained unaffected. It is concluded that the inhibitory action of somatostatin on the vagally induced secretion must be due to an inhibition of the impulse transmission in the efferent parasympathetic nerves to the pancreas, and it is suggested that this mechanism contributes to the inhibitory effect of somatostatin observed with other stimuli as well.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0885-3177
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Somatostatin inhibits neurally stimulated pancreatic secretion indirectly.
pubmed:affiliation
Institute of Medical Physiology C, University of Copenhagen, Denmark.
pubmed:publicationType
Journal Article