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pubmed:abstractText |
TDP-43 is an evolutionarily conserved RNA-binding protein implicated in the pathogenesis of frontotemporal dementia (FTD), sporadic and familial amyotrophic lateral sclerosis (ALS), and possibly other neurodegenerative diseases. In diseased neurons, TDP-43 is depleted in the nucleus, suggesting a loss-of-function pathogenic mechanism. However, the normal function of TDP-43 in postmitotic neurons is largely unknown.
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pubmed:affiliation |
Gladstone Institute of Neurological Disease, and Department of Neurology, University of California, San Francisco, CA 94158, USA. ylu@gladstone.ucsf.edu
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