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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-25
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pubmed:abstractText |
Salmonella enterica utilizes a type III secretion system (TTSS) encoded in its pathogenicity island 1 to mediate its initial interactions with intestinal epithelial cells, which are characterized by the stimulation of actin cytoskeleton reorganization and a profound reprogramming of gene expression. These responses result from the stimulation of Rho-family GTPases and downstream signaling pathways by specific effector proteins delivered by this TTSS. We show here that AvrA, an effector protein of this TTSS, specifically inhibits the Salmonella-induced activation of the JNK pathway through its interaction with MKK7, although it does not interfere with the bacterial infection-induced NF-kappaB activation. We also show that AvrA is phosphorylated at evolutionary conserved residues by a TTSS-effector-activated ERK pathway. This interplay between effector proteins delivered by the same TTSS highlights the remarkable complexity of these systems.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-10499590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-10644492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-10735884,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-11090361,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-16140013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-16212495,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-17074883,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19779561-9630225
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AvrA protein, Salmonella enterica,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Spi1 protein, Salmonella
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1553-7374
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e1000595
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pubmed:meshHeading |
pubmed-meshheading:19779561-Bacterial Proteins,
pubmed-meshheading:19779561-Cell Line,
pubmed-meshheading:19779561-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:19779561-Humans,
pubmed-meshheading:19779561-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:19779561-MAP Kinase Kinase 7,
pubmed-meshheading:19779561-Mutation,
pubmed-meshheading:19779561-NF-kappa B,
pubmed-meshheading:19779561-Phosphorylation,
pubmed-meshheading:19779561-Saccharomyces cerevisiae,
pubmed-meshheading:19779561-Salmonella Infections,
pubmed-meshheading:19779561-Salmonella typhimurium,
pubmed-meshheading:19779561-Secretory Pathway,
pubmed-meshheading:19779561-Signal Transduction,
pubmed-meshheading:19779561-Two-Hybrid System Techniques
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pubmed:year |
2009
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pubmed:articleTitle |
Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA.
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pubmed:affiliation |
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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