19768112

Source:http://linkedlifedata.com/resource/pubmed/id/19768112

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0037083, umls-concept:C0040690, umls-concept:C0149784, umls-concept:C0242606, umls-concept:C0376571, umls-concept:C0851285, umls-concept:C0919432, umls-concept:C1710082
pubmed:issue	9
pubmed:dateCreated	2009-9-21
pubmed:abstractText	BRCA1 is a key regulatory protein participating in cell cycle checkpoint and DNA damage repair networks. BRCA1 plays important roles in protecting numerous cellular processes in response to cell damaging signals. Transforming growth factor-beta (TGF-beta) is a potent regulator of growth, apoptosis and invasiveness of tumor cells. TFG-beta activates Smad signaling via its two cell surface receptors, the TbetaRII and ALK5/TbetaRI, leading to Smad-mediated transcriptional regulation.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA096805, http://linkedlifedata.com/resource/pubmed/grant/CA135226
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101285081
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 Protein, http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide, http://linkedlifedata.com/resource/pubmed/chemical/SMAD3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
pubmed:status	MEDLINE
pubmed:issn	1932-6203
pubmed:author	pubmed-author:AvrahamHava KarsentyHK, pubmed-author:AvrahamShalomS, pubmed-author:LiHuchunH, pubmed-author:SekineMasayukiM, pubmed-author:SengSeyhaS
pubmed:issnType	Electronic
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	e7091
pubmed:meshHeading	pubmed-meshheading:19768112-Animals, pubmed-meshheading:19768112-Apoptosis, pubmed-meshheading:19768112-BRCA1 Protein, pubmed-meshheading:19768112-COS Cells, pubmed-meshheading:19768112-Cell Proliferation, pubmed-meshheading:19768112-Cercopithecus aethiops, pubmed-meshheading:19768112-Gene Expression Regulation, pubmed-meshheading:19768112-Germ-Line Mutation, pubmed-meshheading:19768112-Humans, pubmed-meshheading:19768112-Hydrogen Peroxide, pubmed-meshheading:19768112-Neoplasm Invasiveness, pubmed-meshheading:19768112-Oxidative Stress, pubmed-meshheading:19768112-Smad Proteins, pubmed-meshheading:19768112-Smad3 Protein, pubmed-meshheading:19768112-Transcription, Genetic, pubmed-meshheading:19768112-Transforming Growth Factor beta
pubmed:year	2009
pubmed:articleTitle	BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses.
pubmed:affiliation	Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural