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rdf:type |
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lifeskim:mentions |
umls-concept:C0004057,
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0178702,
umls-concept:C0185117,
umls-concept:C0302350,
umls-concept:C0332281,
umls-concept:C0521447,
umls-concept:C0814225,
umls-concept:C1705162,
umls-concept:C1709059,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2009-10-9
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pubmed:abstractText |
Aspirin-exacerbated respiratory disease is characterized by asthma, nasal polyps, and intolerance to aspirin with overexpression of leukotriene (LT) C(4) synthase and cysteinyl leukotriene receptors. Through an unknown mechanism, aspirin desensitization is an effective treatment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/IL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Ketorolac,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Salicylate,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene D4 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene-C4 synthase,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin-E synthase
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1097-6825
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
724-30.e4
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pubmed:meshHeading |
pubmed-meshheading:19767084-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:19767084-Aspirin,
pubmed-meshheading:19767084-Asthma,
pubmed-meshheading:19767084-Cell Line,
pubmed-meshheading:19767084-Cyclooxygenase 2,
pubmed-meshheading:19767084-Desensitization, Immunologic,
pubmed-meshheading:19767084-Drug Hypersensitivity,
pubmed-meshheading:19767084-Gene Expression,
pubmed-meshheading:19767084-Glutathione Transferase,
pubmed-meshheading:19767084-Humans,
pubmed-meshheading:19767084-Interleukin-4,
pubmed-meshheading:19767084-Intramolecular Oxidoreductases,
pubmed-meshheading:19767084-Ketorolac,
pubmed-meshheading:19767084-Monocytes,
pubmed-meshheading:19767084-Receptors, Leukotriene,
pubmed-meshheading:19767084-STAT6 Transcription Factor,
pubmed-meshheading:19767084-Signal Transduction,
pubmed-meshheading:19767084-Sodium Salicylate,
pubmed-meshheading:19767084-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization.
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pubmed:affiliation |
Carter Immunology Center, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Va., USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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