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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-9-21
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pubmed:abstractText |
Plasticity related gene-1 (PRG-1) is a brain-specific membrane protein related to lipid phosphate phosphatases, which acts in the hippocampus specifically at the excitatory synapse terminating on glutamatergic neurons. Deletion of prg-1 in mice leads to epileptic seizures and augmentation of EPSCs, but not IPSCs. In utero electroporation of PRG-1 into deficient animals revealed that PRG-1 modulates excitation at the synaptic junction. Mutation of the extracellular domain of PRG-1 crucial for its interaction with lysophosphatidic acid (LPA) abolished the ability to prevent hyperexcitability. As LPA application in vitro induced hyperexcitability in wild-type but not in LPA(2) receptor-deficient animals, and uptake of phospholipids is reduced in PRG-1-deficient neurons, we assessed PRG-1/LPA(2) receptor-deficient animals, and found that the pathophysiology observed in the PRG-1-deficient mice was fully reverted. Thus, we propose PRG-1 as an important player in the modulatory control of hippocampal excitability dependent on presynaptic LPA(2) receptor signaling.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-4172
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pubmed:author |
pubmed-author:AokiJunkenJ,
pubmed-author:BattefeldArneA,
pubmed-author:BaumgartJanJ,
pubmed-author:BeedPrateepP,
pubmed-author:BirchmeierCarmenC,
pubmed-author:BräuerAnja UAU,
pubmed-author:BreustedtJörgJ,
pubmed-author:BroseNilsN,
pubmed-author:BrunkIreneI,
pubmed-author:ChunJeroldJ,
pubmed-author:GeistBeateB,
pubmed-author:KawabeHiroshiH,
pubmed-author:KieselmannOlgaO,
pubmed-author:KintscherMichaelM,
pubmed-author:Kishimoto-SugaMikaM,
pubmed-author:LaubeGregorG,
pubmed-author:MaierNikolausN,
pubmed-author:NinnemannOlafO,
pubmed-author:NitschRobertR,
pubmed-author:SavaskanNic ENE,
pubmed-author:SchmitzDietmarD,
pubmed-author:SchuchmannSebastianS,
pubmed-author:SchuelkeMarkusM,
pubmed-author:SendtnerMichaelM,
pubmed-author:StraussUlfU,
pubmed-author:StreuNoraN,
pubmed-author:TrimbuchThorstenT,
pubmed-author:VogtJohannesJ,
pubmed-author:WendeHagenH,
pubmed-author:WieseStefanS
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1222-35
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pubmed:dateRevised |
2011-10-25
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pubmed:meshHeading |
pubmed-meshheading:19766573-Animals,
pubmed-meshheading:19766573-Electroencephalography,
pubmed-meshheading:19766573-Hippocampus,
pubmed-meshheading:19766573-Lysophospholipids,
pubmed-meshheading:19766573-Mice,
pubmed-meshheading:19766573-Mice, Knockout,
pubmed-meshheading:19766573-Proteoglycans,
pubmed-meshheading:19766573-Receptors, AMPA,
pubmed-meshheading:19766573-Receptors, Lysophosphatidic Acid,
pubmed-meshheading:19766573-Signal Transduction,
pubmed-meshheading:19766573-Synapses,
pubmed-meshheading:19766573-Vesicular Transport Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
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pubmed:affiliation |
Institute of Cell Biology and Neurobiology and NeuroCure, Charité, Universitätsmedizin Berlin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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