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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
Whether a high plasma aldosterone concentration induced by strict salt restriction promotes cardiac remodeling remains controversial. Male Sprague-Dawley rats at 10weeks of age were given normal salt (NS) (1.5% NaCl) or low salt (LS) (0.05% NaCl) diets. Each animal underwent aortocaval fistula creation for volume-overloaded heart failure or sham surgery. All rats with a fistula received either vehicle or a non-hypotensive dose of spironolactone (200mg/kg/day) by gavage. Two weeks later, the LS diet significantly increased the plasma aldosterone level in the sham-operated and fistula-created rats (2677+/-662pg/ml and 2406+/-422pg/ml) compared with that in rats given the NS diet (518+/-18pg/ml and 362+/-45pg/ml, respectively). In sham-operated rats, the difference in plasma aldosterone level did not affect the extent of myocardial fibrosis (1.8+/-0.1% with LS diet vs. 1.5+/-0.3% with NS diet). However, the increase in myocardial fibrosis in fistula-created rats was more prominent with the LS diet than with the NS diet (4.7+/-0.3% vs. 3.4+/-0.1%). In addition, the fistula-created rats on the LS diet expressed significantly increased oxidative stress and transforming growth factor-beta compared with those on the NS diets (P<0.05). These increases in the fistula-created rats on the LS diet were significantly suppressed by the non-hypotensive dose of spironolactone (P<0.05). These results suggest that increased plasma aldosterone level with strict salt restriction activated the mineralocorticoid receptor signaling in volume-overloaded condition, resulting in increased myocardial fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1879-0712
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pubmed:author |
pubmed-author:HayashiTetsuyaT,
pubmed-author:KimuraSayakaS,
pubmed-author:KitadaKentoK,
pubmed-author:KitauraYasushiY,
pubmed-author:KobayashiKanaK,
pubmed-author:KurumazukaDaisukeD,
pubmed-author:MatsudaHirohisaH,
pubmed-author:MatsumotoChikaC,
pubmed-author:MatsumuraYasuoY,
pubmed-author:MoriTatsuhikoT,
pubmed-author:ShirakawaHisashiH
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
623
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-8
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pubmed:meshHeading |
pubmed-meshheading:19766104-Aldosterone,
pubmed-meshheading:19766104-Aldosterone Antagonists,
pubmed-meshheading:19766104-Animals,
pubmed-meshheading:19766104-Atrial Natriuretic Factor,
pubmed-meshheading:19766104-Body Weight,
pubmed-meshheading:19766104-Cell Size,
pubmed-meshheading:19766104-Diet, Sodium-Restricted,
pubmed-meshheading:19766104-Endomyocardial Fibrosis,
pubmed-meshheading:19766104-Heart,
pubmed-meshheading:19766104-Heart Failure,
pubmed-meshheading:19766104-Hemodynamics,
pubmed-meshheading:19766104-Hypertension,
pubmed-meshheading:19766104-Male,
pubmed-meshheading:19766104-Myocardium,
pubmed-meshheading:19766104-Myocytes, Cardiac,
pubmed-meshheading:19766104-Natriuretic Peptide, Brain,
pubmed-meshheading:19766104-Organ Size,
pubmed-meshheading:19766104-Rats,
pubmed-meshheading:19766104-Rats, Sprague-Dawley,
pubmed-meshheading:19766104-Receptors, Mineralocorticoid,
pubmed-meshheading:19766104-Signal Transduction,
pubmed-meshheading:19766104-Spironolactone,
pubmed-meshheading:19766104-Transforming Growth Factor beta,
pubmed-meshheading:19766104-Tyrosine,
pubmed-meshheading:19766104-Ventricular Remodeling
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pubmed:year |
2009
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pubmed:articleTitle |
Dietary salt restriction activates mineralocorticoid receptor signaling in volume-overloaded heart failure.
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pubmed:affiliation |
Department of Internal Medicine III, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan. tatmori@poh.osaka-med.ac.jp
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pubmed:publicationType |
Journal Article
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